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Key Takeaways Common MTHFR mutations include C677T (rs1801133) and A1298C (rs1801131), affecting enzyme functionality and folate metabolism

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Interrogation of intracellular neurotrophin signaling pathways with selective inhibitors of MEK1/2, phosphoinositide 3-kinase (PI3K) and tyrosine kinase A (TrkA) suggested the role of ERK pathway in vorinostat-induced neurotrophic action also involved the activation of upstream extracellular kinase TrkA

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