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The IRP/IRE system regulates the expression of mRNAs coding for proteins related to different aspects of iron metabolism (internalization, storage, heme group synthesis, export), such as TfR, ferritin or FPN

In some embodiments, the pH of the formulations or compositions described herein is adjusted (e.g., by use of a buffer) to a perilymphcompatible pH of about 7.0-7.6, and a preferred pH range of about 7.2-7.4

Glutathione is widely found in animals and plants, and the contents of the bread yeast, wheat germ and animal liver are very high,100~100 mg/1000 g;Content is also rich in human and animal blood, such as human blood contains 26~34 mg/100 g, chicken blood contains 58-73 mg/73 g, pig blood contains 10~15 mg/100 g, the dog blood contains 14~22 mg/100 g.Many vegetables, potato and corn also contains GSH (see table 1)

The safer option: look for brightening ingredients like vitamin C, niacinamide, azelaic acid, licorice root extract, and kojic acid, all of which are effective and safe alternatives for brightening and reducing hyperpigmentation, Dr