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Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism

In a rat model, co-administration of Wuzhi tabletsan ethanol extract of Schisandra sphenanthera containing schisandrin, schizandrol B, schisantherin A, schisanhenol, and deoxyschizandrinsignificantly altered cyclosporine A blood levels, suggesting sensitivity to CYP3A/P-gp modulation [118, 119], Wuzhi capsules found that Wuzhi tablets influenced cyclophosphamide metabolism, potentially mitigating its nephrotoxic and hepatotoxic effects

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