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Acetaldehyde was shown to alter cellular respiration in cultured microvascular endothelial hBMVEC cells, which mainly comprise the bloodbrain-barrier, thereby suggesting negative effects on bloodbrain-barrier integrity (121).Further, in cultured primary cortical neurons, acetaldehyde impaired mitochondrial respiration via NOX -mediated activation (122), and in brain mitochondria in vitro , acrolein inhibited mitochondrial respiration via complex I (123)

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With the continued use of smokeless tobacco by high schoolers and college athletes, it will be interesting to see if baseball truly can disentangle itself from tobacco