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Giorello L, Clerico L, Pescarolo MP, Vikhanskaya F, Salmona M, Colella G, et al

They found that angiotensin II levels were significantly elevated in these patients, and this increase was correlated with higher viral loads and more extensive lung injury

In certain embodiments, any controlled-release otic formulation described herein increases the exposure of an active agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 100%, or higher than 100%, compared to an otic formulation that is not a controlled-release otic formulation

Selected targets will be investigated in high-resolution with a spatial resolution from 25 m/pixel down to 2.4 m/pixel with a 1.3 field of view