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Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia

It challenges the conventional perspective on the role of antioxidants in cancer prevention, emphasizing the necessity for judicious selection of antioxidants in clinical applications and the consideration of the network effects of molecular mechanisms

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Secondary effects include NF-B-dependent anti-inflammatory signaling and angiogenic outgrowth driven by endothelial migration into the wound bed