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2), the additive effect of having $\left[ a \right] \& \left[ b \right]$ can be modeled via the concept of dose equivalency

Selected Bibliography Lin, C

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One of the formed products after converting AA by the 5-LO/FLAP complex is leukotriene A4 (LTA4) which is converted by leukotriene C4 synthase (LTC4S) to leukotriene C4 (LTC4)