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The Surviving Sepsis Campaign 2021 guidelines suggest starting AVP at a fixed infusion rate independent of weight (up to 0.03 IU/min) as an early adjunct when NE infusion rates reach 0.250.50 g/kg/min [10, 11], a threshold for AVP initiation that still needs to be validated [12, 13]

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Inositol plays roles in cell signalling and lipid metabolism, though its direct lipotropic effects in humans remain poorly characterised