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The third term is the loss of cysteine in the reaction catalyzed by GCS that makes glutamyl-cysteine and the fourth term represents the loss of cysteine to other pathways (for example to sulfate and taurine)

Marimatsu S, Watanabe K, Matsunaga T, Yamamoto I, Imaoka S, Funae Y: Cytochrome P450 isozymes involved in the oxidative metabolism of delta-9-tetrahydrocannabinol by liver microsomes of adult female rats

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However, researchers speculate that the lack of response may have been due to the low dose of zinc administered (7.5 10 mg) (Kulolu 2011)