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Activation of LDHA by oncogenic receptor tyrosine kinase FGFR1 promotes glycolysis and tumor growth by increasing the NAD + /NADH ratio, 368 while the aberration of NAD + /NADH due to reduced activity of mitochondrial complex I promotes the aggressiveness of human breast cancer cells

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PLoS Pathog 13:e1006744 Han EJ, Kim HY, Lee N, Kim NH, Yoo SA, Kwon HM, Jue DM, Park YJ, Cho CS, De TQ, Jeong DY, Lim HJ, Park WK, Lee GH, Cho H, Kim WU (2017) Suppression of NFAT5-mediated inflammation and chronic arthritis by novel kappaB-binding inhibitors

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