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Researchers should also recognize that the combinations per-unit efficiency means that a well-designed combination protocol frequently achieves a larger research signal at a lower total compound cost than a single-compound protocol producing the same effect, which is part of why the combination dosing approach dominates the published GH-axis research literature

According to research studies, lipoate, a conjugate base of ALA takes part in several oxidative metabolic processes where it is reduced to dihydrolipoate under physiological conditions

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Funding This work was supported by the start-up funds for research from China Medical University (110/1210616002)