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IGF-1 LR3 Potency and Pharmacological Profile Research has demonstrated that both IGF-1 and IGF-1 LR3 exhibit robust bioactivity at the IGF-1 receptor, with IGF-1 LR3 showing superior cell proliferation effects attributable to its reduced IGFBP sequestration with the study concluding that IGF-1 LR3 holds considerable promise for scientific applications, particularly due to its prolonged receptor availability