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Front Surg 2024;11:1265360

Adults above 40 : Overpower age-related decline in glutathione, combating oxidative stress for energy

Specifically, hypoxia-induced glycolysis in PDAC cells provokes the lactylation of lysine 34 on NUSAP1, a spindle microtubule regulator, which enhances its expression by hindering its degradation, consequently establishing an NUSAP1-LDHA-glycolysis-lactate feedforward loop and facilitating metastasis in PDAC