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The intensification phases may reinvigorate improvement that had plateaued during maintenance

Potential muscle-related effects include: Improved body composition Reduced visceral fat Mild increases in lean mass In a randomized, placebo-controlled study in HIV-infected adults with abdominal fat accumulation, daily subcutaneous tesamorelin for six months significantly reduced visceral adipose tissue compared with placebo and also increased trunk and total lean body mass, indicating improved overall body composition beyond just weight changes

This timing allows the injection site to settle while maximizing synergy between systemic and topical delivery

Sitting down for a few minutes helps relieve the brief sensation