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Limitations of traditional target discovery methods Traditional target discovery methods primarily focus on validating single targets and screening potential drugs, often employing techniques such as high-throughput screening (HTS) and in vitro experiments [234, 235]

Besides an increased homocysteine export from tissues into plasma that may be regulated by a reduced-homocysteine carrier (Blom, 2000), hyperhomocysteinemia can result from reduced renal function, which may have a central role in plasma homocysteine clearance, and from chronic hepatic insufficiency

Some people also feel irritable, have trouble coordinating movements, and notice decreased urination