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.,Garca-SnchezA,Miranda-DazAGCardona-MuozEGThe role of oxidative stress in physiopathology and pharmacological treatment with Pro- and antioxidant properties in chronic diseases.2020;2020(1):2082145 79

Studies have shown that subnormal ALP activity and elevated PLP levels can indicate HPP

Conversely, unstimulated microglia appear to bolster the expression of TJ proteins within co-cultured endothelial cells, demonstrating a protective or restorative role of microglia in BBB integrity (Mehrabadi et al., 2017)

Studies also suggest that these nutrients support methylation pathways, which are often disrupted in ASD, thereby improving gene expression and reducing oxidative stress