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1 Introduction Tumor-associated macrophages (TAMs), a dominant immune cell population in the tumor microenvironment (TME), significantly influence cancer progression ( Ferroptosis represents a metabolically driven form of regulated cell death that is fundamentally distinct from apoptosis, necroptosis, and pyroptosis ( Figure 1

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It should be noted that in certain cell types or cell lines, inhibition of GPX4 fails to induce ferroptosis, suggesting the existence of alternative mechanisms

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