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83 Similarly, in pancreatic adenocarcinoma (PAAD), lactylation of NMNAT1 at lysine 128 enhances its nuclear localization and enzymatic activity in PAAD cells, activating the NAD + salvage pathway and promoting cell survival, linking Kla to NAD + metabolism

Stamatiadis D, et al

Age-related conditionssuch as Alzheimer's diseaseare associated with impaired synaptic plasticity mechanisms, suggesting that maintaining robust homosynaptic plasticity might protect cognitive function