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Clinical Study Results (REDEFINE) Cagrilintide is a long-acting amylin analogue: Monotherapy: In REDEFINE-1, cagrilintide monotherapy was associated with approximately 11.8% weight loss

However, while always being within the range of normal values, in healthy rats, it may decrease (pyloric sphincter) or increase (lower esophageal sphincter) the pressure in sphincters and, thereby, it may participate in the anti-reflux mechanism (30-32)

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