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This was fully investigated in 1849, by British physician Thomas Addison, from which it acquired the common name of Addison's anemia

In some instances, a patient can undergo this therapy by using oral peptide supplements or a topical dermal cream

A reduction in liver stiffness but not in liver fat content was shown in subjects who drank more than three cups of coffee a day, thus suggesting that coffee has an antifibrotic effect since caffeine, an adenosine receptor antagonist, reduces fibrogenesis and thus collagen production [37]