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The same as related factors in the Wnt signaling pathway, expression levels of related factors in the BMP signaling pathway, such as BMP2 , BMP4 , BMP7 , and Samd2 , and expression levels of other related factors, such as FGF7 , CYP17 , CXCL13 , EDAR , TGF2 , PI3KB , and Akt , were also comparable

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98 Although berberine has been studied in human clinical trials and shown to have several metabolic benefits, concerns about long-term use of berberine have been raised on the basis of certain preclinical studies