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Selleri S, Bifsha P, Civini S, Pacelli C, Dieng MM, Lemieux W, et al

According to the European Medicines Agency assessment report on HPL, lyophilized 65% ethanol extracts (5:1, 100 mg of extracts were equivalent to 500 mg of HPL) were standardized to 0.3% hypericin and contained 1.09% rutin, 0.65% hyperoside, 0.45% isoquercitin, 0.04% quercitrin, and 0.07% quercetin (the HPL flavonoid content determination is described in Supplementary method I, Supplementary Figure S1, and Supplementary Tables S1, S2)

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Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly