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Cell walls During stress, the cell wall-localized lipoxygenase (LOX) causes hydroperoxidation of polyunsaturated fatty acids (PUFA) making it active source of ROS like OH , O 2 , H 2 O 2 , and 1 O 2

443 AgeXtend, an AI-powered multimodal platform for geroprotective factor discovery, 444 integrates multidimensional biological activity profiles of known longevity-related molecules to (1) predict the pharmacodynamic potential of candidate geroprotectors, (2) systematically evaluate pharmacokinetic properties and toxicity profiles, and (3) elucidate molecular targets and mechanisms of action through deep learning-driven pattern recognition

Some explanations involve chemical messengers of inflammation and pain

Originally identified in gastric juices, this peptide helps protect and repair the digestive tract