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Current senolytic agents are primarily employed in cancer therapies, such as doxorubicin, trametinib, and cell cycle-targeting drugs like palbociclib (Lea et al., 2022

In precancer models induced by MCD, LA aggravates liver damage and promotes the formation of precancer lesions

J Exp Med 201: 15431553 Zivanov J, Nakane T, Forsberg BO, Kimanius D, Hagen WJ, Lindahl E, Scheres SH (2018) New tools for automated highresolution cryoEM structure determination in RELION3

The median age among surviving patients was seven years (range: 1-15 years) and severity of neurocognitive outcome varied from mild learning disability [91,96] to significant impairment [101,103]