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The median CQ (control drug) and MB IC 50 were 28.14 70.8 (range from 7.97 to 243.2) and 2.41 5.36 (range from 0.01 to 18.52) nM, respectively

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When an amylin analogue like cagrilintide is paired with a GLP-1/GIP receptor agonist, the complementary mechanisms appear to produce additive appetite suppression: cagrilintide slows gastric emptying through amylin receptor activation, while tirzepatide simultaneously boosts insulin secretion and reduces glucagon

A linear gradient from 2% (v/v) to 70% (v/v) mobile phase A was applied to retain less polar compounds, including NAC, NAM, and PGlu, while ensuring elution of strongly retained compounds within a reasonable time