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Ann Oncol 15:12101214

MTHFR mutations do not directly compromise gut microbiota diversity

48,49,50,51 Moreover, through the action of two of the enzymes involved in the production of H 2 Scysteine aminotransferase (CAT) and 3-mercaptopyruvate sulphurtransferase (3-MST)cysteine is sequentially converted into 3-mercaptopyruvate (3-MP) with the release of an amino group that will react with -ketoglutarate, ending with the formation of glutamate and pyruvate (Fig