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Preclinical achievements of polymeric nanoparticles-mediated drug delivery in Alzheimers disease Most of the current conventional therapeutics used in the treatment of neurodegenerative disorders, including AD, are based on high molecular weight (Mw 500 Da) Abs, peptides and proteins, which are unable to go through the BBB by themselves (Mukherjee et al., 2020)

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Gradual progression prevents the common pattern of early overexuberance followed by setback