glutathione mitochondrial function and mitochondria Mitochondrial GSH redox cycle and

Figure 2 3.1 Gut microbiota and oxidative environment The gastrointestinal tract contains a major portion of the bodys commensal microbiota, which plays an essential role in regulating enzymatic activity, oxidation, and immune homeostasis (32)

The main gst genes described as polymorphic are those coding for GSTM1-1, GSTT1-1 and GSTP1-1

This not only accelerates cell death but also contributes to the activation of the NLRP3 inflammasome, leading to excessive IL-1 and IL-18 production and driving further inflammation (68, 69)

Second generation CB1 receptor blockers and other inhibitors of peripheral endocannabinoid overactivity and the rationale of their use against metabolic disorders