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The position of the supraorbital and supratrochlear neurovascular bundles, the depth of the SMAS layer over the malar fat pad, the convexity of the zygomatic body, the trajectory of the facial artery as it crosses the mandible, the relationship of the modiolus to the oral commissure, the thickness of the platysma and its decussation pattern across the midline neck, the variant anatomy of the angular and dorsal nasal arteries near the nasal radix: all of these change the safe injection plane, the appropriate cannula or needle, the volume that can be safely deposited, and the technique angle

However, just like any cosmetic procedure, it can also cause some unfavourable side effects

Most individuals find doses in the 50100 mg range welltolerated after rampup [5]

Neurochem Int 61:713720 Pinto MC, Simao F, da Costa FL, Rosa DV, de Paiva MJ, Resende RR, Romano-Silva MA, Gomez MV, Gomez RS (2014) Sarcosine preconditioning induces ischemic tolerance against global cerebral ischemia