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Ultimately, it seeks to safeguard the transformative power of these sacred sites as enduring expressions of a harmonious synthesis between nature and culture, ensuring their relevance and vitality for future generations

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The advent of personalized and engineered probiotics introduces further complexity, as factors such as individual microbiome variability, host genetics, and polypharmacy can influence both the efficacy and safety profiles, thereby complicating standardized evaluation (527, 528)