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Correlation of paraquat toxicity with tissue concentrations and weight loss of the rat

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Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs

GHK-Cu also suppresses the over expression of transforming growth factor-beta (TGF-)1 that has been noted in patients with hereditary hair loss, leading to hair shaft thickening and elongation