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Additionally, their ability to efficiently transduce hepatocytes and cardiac cells makes them suitable for treating liver diseases and cardiovascular conditions

In obese adipose tissue, excessive ROS production from NADPH oxidases and impaired ETCs induces mitochondrial DNA (mtDNA) damage, which escapes into the cytoplasm and circulation as damageassociated molecular patterns (DAMPs), activating TLR9 and NLRP3 inflammasome pathways to trigger proinflammatory cytokine cascades such as IL1 and IL18 [118, 119]

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud