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Chronic 3-NP administration depletes ATP and NAD + levels and increases the release of ILs, TNF-, glutamate, and iNOS [168, 169]

The binding of the SARS-CoV-2 spike glycoprotein with ACE2, which triggers the virus-mediated cellular uptake, can also cause a burst of inflammatory cytokine release (a cytokine storm) partially because of the decreased availability of functional ACE2

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