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In fact, single cell RNA sequencing of transcriptomic differences between quiescent and activated NSCs revealed that gene expression of glycolytic and fatty acid oxidation enzymes is increased during quiescence, switching over to a more oxidative phosphorylation-based transcriptional program upon activation (Shin et al., 2015)

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Dillon et al., in a phase I clinical trial, evaluated a vaccine containing nine breast-cancer-associated peptides (MHC I restricted) from MAGE-A1, 3A3, and AA10 proteins, CEA, NY-ESO-1, and HER2/neu along with a TLR3 agonist, Poly-ICLC, and an adjuvant derived from tetanus toxin