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Macrophage activation is central to PNI pathogenesis, transitioning from a proinflammatory (M1) to an anti-inflammatory (M2) phenotype with distinct functions in inflammation and repair

In cancer cells, increased ROS will oxidize the specific isoform of pyruvate kinase (PKM2), diverting glucose flux towards the PPP and generation of NADPH for GSH recycling

Very small stones can pass through the entire urinary tract without causing symptoms, but larger stones can become lodged in the ureters, bladder, or urethra (NLM 2015

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