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(3) Disruption of membrane integrity: -syn interacts with the Translocase of the Outer Mitochondrial Membrane (TOM) complex (e.g., TOM40, TOM20) and the Voltage-Dependent Anion-Selective Channel 1 (VDAC1), which leads to abnormal membrane permeability (McCarthy et al., 2022)

Itaconate is a metabolite synthesized by cis-aconitate decarboxylase and is produced by lipopolysaccharide-activated macrophages through the diversion of cis-aconitate from the tricarboxylic acid cycle

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