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Oxygen and glucose deprivation lead to the stabilization and/or upregulation of microglial HIF-1 (Xu et al., 2023), which, in turn, results in increased autophagy, TLR4, IL-1, and IL-18 expression, and NLR family pyrin domain containing 3 (NLRP3) inflammasome formation, suggesting HIF-1 contributes to the proinflammatory phenotype of microglia after a stroke event (Guo et al., 2009

Furthermore, with a dose as low as 50 mg, L-theanine was shown to increase alpha brain wave activity, indicating relaxation

The progressive shortening of telomeres leads to senescence, apoptosis, or oncogenic transformation of somatic cells, affecting the health and lifespan of an individual

Dierks, T