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This review attempts to provide some mechanistic insight (Figures 13) into how the bi-directional network between the gut microbiota and the brain can not only protect but also trigger and aid chronic gut inflammation, promote a global pro-inflammatory state, modify and contribute to protein misfolding processes, dysregulate the autophagic-lysosomal protein clearance mechanism, differentiate T-cell subsets to facilitate a deleterious autoimmune response, and finally modulate immune recruitment and BBB status

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Most patients stay on a combined protocol for at least three to six months to experience optimal results

Prevention of fistulas and stenosis Patients with IBD are often accompanied by intestinal fistula or intestinal cavity stenosis