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Seminal oxidative stress indices Few studies demonstrated improvement in OS as determined by reduction of levels of malonaldehyde (MDA), a lipid peroxidation byproduct following therapy with Vitamin C, vitamin E, beta-carotene, zinc, selenium, and NAC when used alone or in combination (107111)

Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)

Graphs were generated with Prism 9 (GraphPad)

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