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Ambati S, Ferarro AR, Kang SE, Lin J, Lin X, Momany M, Lewis ZA, Meagher RB

No significant adverse effects have been reported from animal studies or first-hand human experiences

The impressive data supporting the role of deacetylation by HDACs in epilepsy arises from the study that the interaction of HDAC3 with MADS-box domain of MEF2 results in MEF2 deacetylation in nucleus and the decrease of MEF2 transcription [74]