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Indeed, previous studies indicate that Nfe2l2 , along with NRF2 target genes such as Gclc and Gclm , exhibits circadian oscillations in the lung, as well as kidney, and aorta (58, 59)

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Increasing levels of VitB12 in humans have been shown to lead to a decline in 24-h mean melatonin levels and nocturnal melatonin levels during bright-light exposure, thereby disrupting the sleep-wake cycle toward increased alertness and decreased sleep duration [21, 38]

This article focuses on current research exploring the proposed mechanisms of action behind BPC-157 and its role in cellular processes