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Moreover, GI comorbidities such as IBS are frequently observed in CFS/ME, further supporting the hypothesis that gut microbiota imbalances are not merely a consequence of illness but may actively contribute to its pathogenesis (He et al., 2023)

154,155 PTEN is an ASD risk gene located on chromosome 10q23 that encodes a lipid specific for phosphatidylinositol (3,4,5)-triphosphate (PIP3), which is a negative regulator of PI3K/AKT/mTORC1 signalling upstream of TSC1/TSC2, resulting in symptoms of ASD