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By promoting the cell-mediated immune response and up-regulating IL-2 and interferon-gamma (IFN-), while down-regulating IL-1, IL-6, TNF- and granulocytemacrophage colony-stimulating factor (GM-CSF), sulforaphane suppresses the metastasis [39]

Together, these findings indicate that while strong oxidants, such as H 2 O 2 , favor irreversible thiol overoxidation and suppress disulfide chemistry, reactive nitrogen species provide a physiologically relevant pathway for disulphide cross-linking of TTR

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