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The number of participants with gastrointestinal disorders was higher with cagrilintide than with pooled placebo (63% vs

Abnormal accumulation of fluidedema, ascites, pleural effusioncan markedly increase the volume of distribution of drugs such as gentamicin that are hydrophilic and have small volumes of distribution

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Patients should use non-oral contraceptive methods or add a barrier method for 4 weeks after tirzepatide initiation and after each dose increase