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To minimise gastrointestinal risks: Take ibuprofen with or after food Use the lowest effective dose for the shortest duration necessary Avoid exceeding 1,200 mg daily (for over-the-counter use) unless advised by a clinician Consider gastric protection (e.g., proton pump inhibitors) if prolonged use is necessary or if risk factors for peptic ulceration exist, as per NICE guidance Maintain good hydration, particularly if experiencing Wegovy-related gastrointestinal effects Special considerations apply to certain groups: Pregnancy and breastfeeding : Ibuprofen should be avoided during pregnancy, particularly after 20 weeks, unless specifically advised by a doctor

NNMT had previously been identified as upregulated in obese adipose tissue, several solid tumours, and ageing tissue more broadly, where its activity correlates with depleted SAM and elevated 1-methylnicotinamide (MNA)

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Isolating the effect of AOD 9604 from these confounding factors is impossible outside of controlled trials