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10.1016/S0306-4522(02)00292-0 10 ArvidssonO.GillbergC.LichtensteinP.LundstromS

Recent studies show that FSP1, when recruited to the plasma membrane, functions as an oxidoreductase reducing ubiquinone (coenzyme Q10, CoQ 10 ) to ubiquinol (CoQ 10 H 2 ), which acts as a lipophilic radical-trapping antioxidant to inhibit ferroptosis, and therefore it was renamed as ferroptosis suppressor protein 1 (FSP1) 32,33

Mouse lymphoma model and tumor xenografts The previously described mouse model of Burkitt lymphoma C57BL/6N-Tg(IGL-MYC)3Hm (-MYC mice) [35] was obtained from the NCI mouse repository (Strain code 01XA7), backcrossed to C57BL/6J for more than 10 generations, and maintained in heterozygosity in a C57BL/6 J background