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(158) demonstrated that colonization of germ-free (GF) mice with a cocktail of 46 Clostridium (primarily belonging to clusters IV and XIVa ) robustly increases Foxp3+ Treg numbers in the colonic lamina propria (LP) without affecting small intestinal Tregs

In other words, the preclinical signal appears against a backdrop of controlled energy intake and activity, not as a standalone effect that overrides diet

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DoW SBIR/STTR Components are now also required to notify SBCs of denial determinations, a new transparency obligation intended to give companies actionable feedback