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Hu L, Hofmann J, Jaffe RB

It can also decrease the cellular action of circulating thyroid hormones, potentially interfering with medications like Levothyroxine used for hypothyroidism, which could paradoxically worsen fatigue if unmonitored

Oxidative stress Oxidative stress is a result of elevated exposure of cells to reactive oxygen species (ROS) e.g

16,326 In conditions of nutrient excess, as seen in T2DM, insulin resistance blunts insulin-mediated nutrient and energy responses, impairing nerve metabolism and bioenergetic failure