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Level B Support: The THH study in CFA arthritis mice showed that intervention corrected bile acid profile abnormalities and improved inflammation, but these effects vanished under ABX pseudo-germ-free conditions, placing bile acid metabolic shifts within a microbiota-dependent chain ( Level C Consistency Supplement: Multiple Level C studies indicate broad-spectrum metabolic dysregulation in RA models, with treatment driving regression toward a healthy state across multiple pathways, paralleling microbiota structural improvement and inflammation reduction

Eur J Biochem 1997