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and how to interpret dosing protocols from published animal studies

261, 262 Although high rates of efficacy were reported (47 to 64%), given the extremely small combined sample size of fewer than 30 patients, the relatively serious AEs (e.g., new diabetes onset, exacerbation of existing diabetes, pneumonia with septic shock, increased blood pressure), and the known risks of systemic long-term glucorticoid use, risks/burdens clearly outweigh benefits and the Panel recommends that this therapy not be used long-term

Restoring Cytokine Balance in HIV-Positive Individuals with Low CD4 T Cell Counts

doi: 10.1016/j.envpol.2023.122211 74 ZouZHuWKangFXuZLiYZhangJet al